Job Description
This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description We are seeking a Structural Evolutionary Biologist to join Invivyd’s Research and Development Team. The ideal candidate brings a strong foundation in molecular evolution, protein structure and computational analysis, with the ability to translate large-scale sequence data into mechanistic insights that inform therapeutic monoclonal antibody development. • Lead an effort that coordinates inputs from microbiologists, evolutionary biologists and antibody engineers to guide programming efforts to develop bioinformatic tools for use in antibody discovery and development • Analyze large sequence datasets to identify evolutionary trends, structural constraints, variant hotspots, and functional motifs in multiple viral target proteins • Develop, maintain, and optimize computational pipelines for sequence processing, structural prediction, phylogenetic analysis, and evolutionary modeling • Curate wastewater and clinical sequence database connectivity pipelines • Support protein engineering and antibody programs by providing structural and evolutionary risk assessments and actionable insights • Generate figures and animations that effectively communicate observed trends in virus evolution and target structural dynamics • Author non-clinical study reports related to pathogen surveillance in support of regulatory filings • Serve as primary point of contact for collaborations and contracts with external partners • Manage a team of programmers and developers • Collaborate closely with cross-functional teams, including other research and development groups, preclinical, clinical and regulatory teams Qualifications • PhD in a relevant scientific discipline (e.g., Computational Biology, Evolutionary Biology, Molecular Biology, Structural Biology, Biochemistry, Immunology, Microbiology) • Demonstrated expertise in microbial molecular evolution, sequence analysis, and phylogenetics • Experience working with large biological data sets and establishing quality assessment workflows for regularly updated databases • Programming skills in Python and JavaScript • Proficiency in design and maintenance of customized computational biology tools and cloud-based bioinformatics suites • Experience in managing CROs and external collaborations, including budgeting and timeline management • Strong problem-solving skills and the ability to adapt to evolving project needs • Excellent verbal and written communication skills • Ability to work independently as well as part of a multidisciplinary team • Highly organized with strong attention to detail • Inclusion of a coding portfolio as part of the application (a link to GitHub repository is preferred) • At least 2 years of experience in the pharmaceutical or biotechnology industry, with a focus on antibody drug discovery and development or infectious diseases - preferred • Experience with SARS-CoV-2 research or similar virology-related projects - preferred • Experience in regulatory interactions and patenting strategies - preferred Company Description At Invivyd, Inc., we take those numbers very seriously and we come to work each day on a mission to deliver protection from serious viral infectious diseases, beginning with SARS-CoV-2. Invivyd deploys a proprietary integrated technology platform unique in the industry designed to assess, monitor, develop, and adapt to create best in class antibodies. • In March 2024, Invivyd received emergency use authorization (EUA) from the U.S. FDA for a monoclonal antibody (mAb) in its pipeline of innovative antibody candidates. • In October 2025, the FDA cleared the company's Investigational New Drug (IND) application and provided feedback to advance the company's REVOLUTION clinical program, Invivyd's development program for VYD2311, a vaccine alternative monoclonal antibody being investigated for the prevention of COVID-19. Apply tot his job